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Research Article | Volume: 1, Issue: 1 Published Date: May 28, 2025 Nanomedicine and Al: The Future of Targeted Drug Delivery and DiagnosticsAuthor(s): Soren Falkner Abstract: Nanomedicine, an interdisciplinary field leveraging nanotechnology, is poised to revolutionize healthcare through the development of highly specific drug delivery systems and ultra-sensitive diagnostic tools. By manipulating materials at the nanoscale. (1-100 nanometers), researchers are engineering novel approaches to overcome limitations in conventional medicine. Targeted drug delivery via nanoparticles offers the potential to enhance therapeutic efficacy by precisely delivering payloads to diseased cells or tissues, minimizing off-target effects and improving patient outcomes. |
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Research Article | Volume: 1, Issue: 1 Published Date: April 16, 2025 Bioanalytical Method Development and Validation for the Estimation of Ripretinib and its Pharmacokinetic Study in Rat Plasma by LC-MSAuthor(s): Shyamala M*, Vishal P and Lalini V Abstract: In this study, sensitive liquid chromatography coupled with the tandem mass spectrometry (LC-MS/ MS) method was developed and validated for the determination of Ripretinib in rat plasma. Liquid-liquid extraction using dichloromethane allowed successful separation of the analyte and internal standard (IS) Sorafenib on an Agilent Zorbax SB C18column with a mobile phase consisted of a mixture of Tetrahydrofuran: 0.2% formic acid solution (80:20, % v/v) delivered at a flow rate of 0.9 mL/min. Mass spectrometric detection was operated in positive multiple reaction monitoring (MRM) mode. The ion transitions monitored were 510.09 → 94.06 for Ripretinib, m/z 465.09 → 185.07 for the IS. |
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